FindTrial
Sign In

Study of gut microbiota and ocular surface microbiota changes in glaucoma patients with Helicobacter pylori infection

Effect and Mechanism of gut microbiota induced Caspase-8 mediated microglia inflammatory activation in glaucomatous optic neuropathy.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400089216
Enrollment
Unknown
Registered
2024-09-04
Start date
2024-09-10
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Interventions

glaucoma group:No intervention
H.pylori group:No intervention
glaucoma with Hp group:No intervention
Healthy control:No intervention

Sponsors

Xiangya Hospital ,Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Subjects aged between 18 to 70 years; 2.Subjects diagnosed with H. pylori infection according to the diagnostic criteria 3.Clinical diagnosed with primary open angle glaucoma

Exclusion criteria

Exclusion criteria: 1. Contact lenses wearing within 1 week; 2.Eyelid and conjunctiva diseases; 3. Ocular surgeries within 6 months or refractive surgeries within 2 years; 4.Use of ocular medications or nutritional tear supplements; 5.Systemic diseases such as Hypertension, Diabetes Mellitus, Parkinson’s disease, Sjogren’s syndrome, rheumatoid arthritis, systemic lupus erythematosus and Grave’s disease; 6. Previous treatment for H.pylori; 7. Use of any antibiotics or probiotics within half a month

Design outcomes

Primary

MeasureTime frame
Changes in gut microbiota composition;—

Secondary

MeasureTime frame
Changes in gut microbiota composition;—

Countries

China

Contacts

Public ContactGuo Yinjie

Xiangya Hospital ,Central South University

22022240@csu.edu.cn+86 137 8616 4710

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026