Acute mountain sickness
Conditions
Interventions
Acetazolamide Intervention Group:Take 500 mg of acetazolamide daily (250 mg each time, twice a day) for 1-3 days. On the 4th day, travel to Litang by car. Continue taking acetazolamide for days 4-6.
Methazolamide Intervention Group:Take 200 mg of methazolamide daily (100 mg each time, twice a day) for 1-3 days. On the 4th day, travel to Litang by car. Continue taking methazolamide for days 4-6.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Never been to an altitude above 2,500 meters 2) Han ethnicity 3) Age between 18 and 60 years (inclusive) 4) Previously healthy individuals with no history of chronic diseases, surgeries, or mental disorders; non-smokers (or those who have not smoked more than 400 cigarette-years, e.g., 20 cigarettes per day for 20 years) and no history of alcohol abuse or other bad habits 5) Normal blood pressure (systolic pressure <140 mmHg; diastolic pressure <90 mmHg) 6) No cardiovascular or pulmonary diseases and not taking any chronic medications 7) Normal levels of blood glucose, blood lipids, complete blood count, and liver and kidney function tests
Exclusion criteria
Exclusion criteria: 1) Presence of contraindications for carbonic anhydrase inhibitors 2) Obesity (body mass index =30 kg/m²) 3) Cardiovascular and respiratory diseases 4) Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is acute mountain sickness occurring;Is high-altitude pulmonary edema occurring;Respiratory sleep monitoring;Adverse drug event; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6 minute walk experiment;blood routine examination;blood biochemistry;Vital signs;Exhaled nitric oxide levels; | — |
Countries
CHINA
Contacts
Public ContactLuo Fengming
West China Hospital, Sichuan University
Outcome results
None listed