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Effect of Teprenone on morphine-induced pain sensitization and analgesic tolerance

Effect of Tepredone on the formation of analgesic tolerance in morphine pain process and its mechanism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089181
Enrollment
Unknown
Registered
2024-09-03
Start date
2023-08-01
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer pain

Interventions

Experimental group:Advanced cancer pain was treated with morphine and tipredone orally
control group:Only morphine was taken orally to treat cancer pain

Sponsors

Yunnan First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Cancer pain patients with middle and advanced tumors who need to receive drug analgesia; 2. Patients who can tolerate morphine therapy; 3. Patients who can be treated with tepredone;

Exclusion criteria

Exclusion criteria: 1. Patients with multiple organ failure who cannot tolerate drug treatment; 2. Patients allergic to morphine and tipredone; 3. Patients with a history of long-term opioid use or drug abuse; 4. Patients who are unwilling to cooperate; 5. Other patients with special medical history who are not suitable for this study; 6. Patients who are taking an increased adverse reaction due to interaction with the experimental drug; 7. Patients allergic to the experimental drug; 8. Patients with other conditions deemed unsuitable for participation by the investigator.

Design outcomes

Primary

MeasureTime frame
Numerical Rating Scale;Daily dose of morphine;Karnofsky Performance Scale;

Countries

China

Contacts

Public ContactJin Hua

Yunnan First People's Hospital

jinhuakm@163.com+86 138 8866 8869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026