aneurysmal subarachnoid hemorrhage
Conditions
Interventions
Control group:Remote ischemic conditioning at a pressure of 60 mmHg was administered twice, once 12 hours before EVT treatment and once 6 hours before.
Therapy group:Remote ischemic conditioning at a pressure of 200 mmHg was administered twice, once 12 hours before EVT treatment and once 6 hours before.
Sponsors
The first hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with a clear clinical diagnosis of aneurysmal subarachnoid hemorrhage (confirmed by imaging examination) and who received endovascular treatment (stent-assisted aneurysm embolization) within 24 hours of admission, regardless of gender; (2) Hunt-Hess score is grade ? - ?; (3) The subject or his/her legally authorized agent is able to provide informed consent. (4) The mRS before the onset was = 1 point.
Exclusion criteria
Exclusion criteria: (1)Patients with multiple intracranial aneurysms or unruptured intracranial aneurysms; (2)Patients with a history of atrial fibrillation or those with atrial fibrillation shown on an electrocardiogram; (3)Patients who have received remote ischemic conditioning therapy within the past three months; (4)Patients with contraindications to remote ischemic conditioning therapy, such as severe soft tissue injury, fractures, or vascular injuries in the upper limbs; acute or subacute deep vein thrombosis in the compressed limb; arterial occlusive disease; =50% stenosis of the subclavian artery or subclavian steal syndrome; (5)Patients with abnormal coagulation function; (6)Patients with ALT or AST levels more than three times the upper limit of normal, or other severe liver diseases; patients with severe renal insufficiency or a creatinine clearance rate 265 µmol/L; (7)Patients with systolic blood pressure >180 mmHg in both upper limbs; (8)Patients with poor temporal window penetration; (9)Patients with an expected life expectancy of less than three months or who, for other reasons, are unable to complete the study; (10)Patients unwilling to be followed up or with poor treatment compliance, or those currently participating in other clinical studies; (11)Other situations deemed unsuitable for enrollment by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cerebral vasospasm during EVT; | — |
Secondary
| Measure | Time frame |
|---|---|
| The degree of cerebral vasospasm during EVT in both groups ;The incidence and degree of cerebral vasospasm in both groups before and after EVT as measured by TCD;The difference in the incidence of thrombotic events during EVT between the two groups; The difference in the incidence of thrombotic events after EVT between the two groups. ;The difference in the incidence of rebleeding within 72 hours after EVT between the two groups (including intraoperative bleeding: defined as extravasation of contrast agent from the aneurysm observed by DSA during surgery). ;The immediate post-EVT aneurysm embolization status in both groups, classified according to the Raymond-Roy scale into three grades: Grade I for complete embolization (no contrast filling in the aneurysm sac or neck); Grade II for near-complete embolization (contrast filling in the aneurysm neck but not in the sac); Grade III for partial embolization (contrast filling in the aneurysm sac).; | — |
Countries
China
Contacts
Public ContactXuan Chen
The first hospital of Jilin University
Outcome results
None listed