Postoperative nausea and vomiting
Conditions
Interventions
Oliceridine group:Anesthetic drugs using oliceridine
Fentanyl group:Anesthetic drugs using fentanyl
Sponsors
Dongtai People's Hospital, Jiangsu Province
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: A simplified adult PONV risk score of =3 points is used for female patients undergoing elective laparoscopic cholecystectomy, laparoscopic uterine and ovarian surgery under general anesthesia; ASA classification I-III level; BMI is 18.5-29.9kg/m2; Obtain informed consent from patients.
Exclusion criteria
Exclusion criteria: History of surgery under general anesthesia within one month prior to surgery; Preoperative severe cardio pulmonary cerebral system diseases, such as severe hypertension (crisis), severe diabetes (ketosis, acidosis), coronary heart disease, COPD, Asthma, respiratory failure, pulmonary arterial hypertension, severe arrhythmia (atrial fibrillation, atrioventricular block at or above II degree, sick sinus syndrome, etc.), severe heart valve disease, heart failure, renal failure, Stroke and myocardial infarction within 6 months, Alzheimer's disease, Parkinson's disease, mental illness, OSS, myasthenia gravis, etc; History of chronic pain; Patients with liver and kidney dysfunction and leukopenia; Individuals with a history of allergies to drugs used in the study; Patients with a history of inflammatory bowel disease or peptic ulcer; those with abnormal coagulation function; METS<4; Tumor patients undergoing radiotherapy and chemotherapy; The patient refusal or inability to cooperate in participating in this study; Patients who participate in other studies within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of nausea and vomiting in patients 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient postoperative nausea and vomiting severity score (VAS) and salvage rate at 48 hours;Postoperative NSAIDs medication rescue frequency and total rescue dosage;VAS scores for resting pain and exercise pain at 24h, 48h after surgery and before discharge;Complications during surgery and anesthesia recovery period; | — |
Countries
China
Contacts
Public ContactJiangfeng Zhao
Dongtai People's Hospital, Jiangsu Province
Outcome results
None listed