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Evaluation of the clinical efficacy and mechanism of action of the lifting and sinking and removing stasis and turbidity granules in the treatment of coronary heart disease (qi deficiency and phlegm stasis syndrome)

Evaluation of the clinical efficacy and mechanism of action of the lifting and sinking and removing stasis and turbidity granules in the treatment of coronary heart disease (qi deficiency and phlegm stasis syndrome)

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089100
Enrollment
Unknown
Registered
2024-09-02
Start date
2024-09-15
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

Study Group:Western medicine basic treatment + ascending depression and stasis removal of turbidity granule group
Control group:Western medicine basic treatment + ascending depression and stasis and turbidity granules placebo group
Coronary heart disease phlegm turbidity and blood stasis syndrome group:None
Coronary Heart Disease Qi Deficiency Phlegm Stasis Syndrome Group:None
Healthy individuals with peaceful quality group:None

Sponsors

The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Age between 18~75 years old; (2) Patients with angina pectoris with coronary heart disease, with typical angina symptoms or equivalent symptoms, angina CCS grade I to III; (3) TCM syndrome differentiation is phlegm turbidity blood stasis pattern, qi deficiency phlegm stasis pattern; (4) Those who voluntarily sign a written informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with acute myocardial infarction, pulmonary embolism and acute cerebrovascular disease within 3 months before enrollment; (2) Patients with severe heart failure (cardiac function grade III-IV), malignant arrhythmia and other heart diseases: valvular heart disease, heart dilatation disease, hyperheart disease, pulmonary heart disease, atrial fibrillation, etc.; (3) Those with poor control of hypertension and diabetes after adjusting treatment; (4) Patients with severe liver and kidney diseases or cachexia in the terminal stage of malignant tumors; (5) Patients with active tuberculosis or rheumatic immune diseases; (6) Patients with hematological diseases, organ transplantation and uremia; (7) Those who are mentally ill and have poor disease control and drug addicts who have not recovered from drugs; (8) Those who participated in other research projects in the past 1 month; (9) Pregnant or lactating females;

Design outcomes

Primary

MeasureTime frame
Cardiopulmonary exercise peak metabolic equivalent;

Secondary

MeasureTime frame
Evaluation of the efficacy of TCM syndromes;Seattle Angina Scale;Cardiopulmonary exercise test;Incidence of MACE;

Countries

China

Contacts

Public Contactyongxia Wang

The First Affiliated Hospital of Henan University of Traditional Chinese Medicine

www.wyxchzhq@163.com+86 138 3857 1596

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026