postoperative delirium
Conditions
Sponsors
The General Hospital of the Western Theater Command
Eligibility
Sex/Gender
All
Age
80 Years to 100 Years
Inclusion criteria
Inclusion criteria: The subjects must meet the following conditions: (1) Patients who are scheduled to undergo orthopedic surgery; (2) Age 80 to 100 years old; (3) The American Society of Anesthesiologists grades I to III; (4) BMI between 18-25kg/m2; (5) No contraindications for general anesthesia; (6) Preoperative self description and family statement of subjective memory decline, with a score of 15-24 on the Beijing version of the Montreal Scale (MoCA); (7) The Mini Mental State Scale (MMSE) score is = 27 points, and (8) the Clinical Dementia Rating Scale (CDR) is 0 5 points; (9) The daily living ability scale (ADL) score is = 26 points.
Exclusion criteria
Exclusion criteria: (1) Preoperative neurological disorders that affect cognitive function (such as vascular dementia); (2) Severe liver and kidney dysfunction (ALT or AST exceeding the upper limit of normal by 1.5 times, creatinine or urea nitrogen exceeding the upper limit of normal); (3) Severe respiratory system diseases; (4) Severe cardiovascular disease; (5) Recently taking sedatives or antidepressants; (6) Taboos for nasal administration; (7) Individuals who are allergic to insulin; (8) Administer insulin to patients through other means.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POD incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extracellular regulated protein kinases;cAMP-response element binding protein;Brain-derived neurotrophic factor; | — |
Countries
China
Contacts
Public ContactHuang Qingqing
The General Hospital of the Western Theater Command
Outcome results
None listed