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Clinical study on Probio-Fit in alleviating intestinal microbiota imbalance caused by antibiotic treatment in CAP patients

Clinical study on Probio-Fit in alleviating intestinal microbiota imbalance caused by antibiotic treatment in CAP patients

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089089
Enrollment
Unknown
Registered
2024-09-02
Start date
2023-11-01
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pneumonia

Interventions

experimental group:Probio-Fit
control group:Conventional antibiotic treatment

Sponsors

Weihai Municipal Hospital Affiliated to Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Age: 18-75 years old; (2) Meets CAP diagnostic criteria; Intravenous application of similar antibiotics; (3) Non severe pneumonia, the condition is temporarily stable, and medication can control the stage; (4) Informed and willing to participate in research and sign an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Pregnant women or lactating patients; (2) Female patients who have not used any contraceptive measures; (3) Patients with unstable vital signs and unstable conditions; (4) Severe pneumonia patients; (5) Combined with severe primary diseases such as active malignant tumors, stroke, and myocardial infarction; (6) Patients with a history of gastrointestinal diseases such as gastrointestinal bleeding, irritable bowel syndrome, Crohn's disease or ulcerative colitis, and a history of gastrointestinal surgery; (7) Patients with a history of mental illness; (8) Patients who have taken antibiotics, glucocorticoids or other immunosuppressive agents, foods or drugs containing probiotics or prebiotics within the past month; (9) Individuals who are allergic to the test sample or exhibit obvious gastrointestinal symptoms such as intolerance; (10) Simultaneously receiving other clinical trial patients; (11) Those who have been determined by the researcher to be unable to complete the research on time.

Design outcomes

Primary

MeasureTime frame
Intestinal microbiota metagenome;

Secondary

MeasureTime frame
Gastrointestinal symptoms;Quality of life;Symptom relief time;Discharge time;

Countries

China

Contacts

Public ContactLiu Ailing

Weihai Municipal Hospital Affiliated to Shandong University

liuailing0730@163.com+86 186 6037 7730

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026