Mild Cognitive Impairment
Conditions
Interventions
A:Left DLPFC-Left IPL 60Hz-tACS
B:Left DLPFC-Left IPL 4Hz-tACS
C:sham tACS
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 65 years or older; (2) Cognitive concern reflecting a change in cognition reported by patient self or informant or clinician, scores on cognitive tests for individuals with MCI are 1.5 standard deviations below the mean for their age and education-matched peers on culturally appropriate normative data; (3) Preservation of independence in functional abilities. (4) Except for other conditions that can cause cognitive impairment, not demented with a CDR score of 0.5; (5) Right handness.
Exclusion criteria
Exclusion criteria: (1) Physical disability; (2) Significant communication and mobility difficulties; (3) Severe vision loss; (4) History of otitis media, Meniere's disease, episodes of vertigo, ototoxic drug use, and family history of deafness; (5) Severe physical illness (e.g., chronic illnesses such as hypertension, heart disease, severe liver disease, etc., except when the illness is stable under medication control); (6) Central nervous system disorders such as epilepsy, cerebrovascular disease, traumatic brain injury, infectious encephalopathy, brain tumors, dementia, etc; (7) Patients with major depression, schizophrenia, presence of psychotic symptoms, depressive episodes, suicidal ideation or behavior, and other psychiatric symptoms that may interfere with the implementation of the research protocol, and long-term psychotropic medication; (8) Any previous active immunotherapy 6 months prior to screening; (9) Alcohol use within 30 days, history of alcohol dependence, and other psychoactive substance abuse (10) Patients with contraindications (e.g. presence of pacemaker and metal implant) to MRI scanning; (11) Those who are unable to complete cognitive function tests due to various conditions; (12) Those attending other clinical trials 30 days prior to screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| repeatable battery for the assessment of neuropsychological status;auditory verbal learning test; | — |
Secondary
| Measure | Time frame |
|---|---|
| working memory task;executive functions;changes in Neuroimage changes in Magnetic Resonance Imaging;changes in electroencephalogram; | — |
Countries
China
Contacts
Public ContactXinyi Cao
Shanghai Mental Health Center
Outcome results
None listed