Dementia, Depression
Conditions
Interventions
Experimental :Computerized cognitive training then treatment as usual
Control :Treatment as usual then computerized cognitive training
Sponsors
CUHK Direct Grant
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are Chinese individuals aged 65 and older, and having a clinical diagnosis of dementia, as supported by a global Clinical Dementia Rating (CDR) score of 1, and ii) having major depressive disorder (single or recurrent episodes without psychotic features, which occur after the onset of dementia, as supported by scoring above the cutoff in the Cornell Scale for Depression in Dementia, CSDD).
Exclusion criteria
Exclusion criteria: Those with suicidal ideation, psychotic symptoms, or are treatment-resistant (history of electroconvulsive therapy, transcranial magnetic stimulation, or no clinical response to 2 or more different classes of antidepressants) will be excluded and referred to the psychiatric services of the Hospital Authority. Other exclusion criteria are non-Chinese ethnicity, having a history of or ongoing substance abuse, mania, bipolar or psychotic disorder, personality disorder, or depression due to organic causes; having language barrier or impairment in communication due to poor vision or hearing despite correction; or having no family member or carer to escort them to centre for training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mood symptoms ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognition;Functioning ;Serum BDNF level ; | — |
Countries
China
Contacts
Public ContactAllen Ting Chun LEE
Chinese University of Hong Kong
Outcome results
None listed