The effects of different interventions on perioperative neurocognitive disorders in elderly patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400089071

Enrollment

Unknown

Registered

2024-09-01

Start date

2024-09-01

Completion date

Unknown

Last updated

2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative neurocognitive disorders

Interventions

dexmedetomidine group (Group D):A loading dose of dexmedetomidine 0.5 µg/kg was given intravenously 10 min before anesthesia induction and pumped for 10 min, followed by adjusting the infusion parame

stellate ganglion block group (Group S):Ultrasound-guided right stellate ganglion block was performed 10 min before anesthesia induction by injecting 5 ml of 0.2% ropivacaine hydrochloride injection,

control group (Group C):Intravenous injection of equal amount of 0.9 % physiological saline.

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients who underwent laparoscopic surgery under elective general anesthesia in Haikou People's Hospital; 2. Diagnosed with type 2 diabetes mellitus; 3. Aged =60 years, no gender limit; 4. ASA grade I to III; 5. 18 kg/m^2<= body mass index (BMI) <=30kg/m^2; 6. Written informed consent signed by the person or legal representative; 7. Able to understand the research process and scale content, and able to communicate effectively with researchers.

Exclusion criteria

Exclusion criteria: 1. Severe cardiopulmonary insufficiency; 2. Severe hepatic and renal dysfunction; 3. Long-term use of sedative and analgesic drugs; 4. Pre-operative presence of severe neuropsychiatric disorders; 5. Preoperative users of antiepileptic drugs and antipsychotics; 6. Hypersensitivity to dexmedetomidine and ropivacaine and contraindications to their use; 7 .Persons with visual and hearing impairments that prevent them from communicating; 8. Those who are unwilling to cooperate for subjective or objective reasons; 9. Preoperative MMSE score for those with cognitive dysfunction (illiteracy =17 points, elementary school education =20 points, middle school education and above =24 points); 10. Abnormal coagulation function (PT (prothrombin time) >ULN+3s and/or APTT (activated partial thrombin time) >ULN+10s).

Design outcomes

Primary

Measure	Time frame
mini-mental state examination;S100 calcium-binding protein ß;neurofilament light chain protein;miR-532-5p;	—

Secondary

Measure	Time frame
VAS score;Athens Insomnia Scale, AIS;	—

Countries

CHina

Contacts

Public ContactYi Tian

Haikou People's Hospital

tianyi1975@126.com+86 138 7682 6960

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026