Preoperative anxiety
Conditions
Interventions
Group C:using normal saline nasal spray
Group D1:using Dextrome nasal spray 50ug
Group D2:using Dextrome nasal spray 75ug
Group D3:using Dextrome nasal spray 100ug
Sponsors
The Second Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing radical mastectomy under general anesthesia; 2) Patients aged 18-65 years; 3) ASA grade I-II; 4) Fully understand the purpose and significance of this experiment, voluntarily participate in this experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Subjects who are not considered suitable for nasal spray by the researchers (such as severe rhinitis, nasal deformity, etc.); 2) Subjects with a history of myocardial infarction or unstable angina pectoris within 6 months prior to the screening period; 3) Subjects with heart rate 2 times the upper limit of normal, or total bilirubin >1.5 times the upper limit of normal; Subjects with serum creatinine (Cr)>1.5 times the upper limit of normal. 9) Subjects with hypothyroidism 10) Those who are allergic to dexmedetomidine, propofol, opioids and other drug ingredients or components to be used in this test; 11) Pregnant or lactating women; 12) Those who planned to have a child between 30 days before the screening period and six months after the end of the trial, were unwilling or unable to take effective contraceptive measures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety scores :1 day before surgery, after dextrometin nasal spray, 12 hours after surgery and 1 day after surgery;Sleep scores: 12h and 1d after surgery;VAS scores: 12h and 1d after surgery; | — |
Countries
China
Contacts
Public ContactHe Hefan
The Second Affiliated Hospital of Fujian Medical University
Outcome results
None listed