hip fracture
Conditions
Interventions
Preoperative one-day block:Iliac fascia block with bupivacaine liposome was received one day before surgery (12-24h before surgery)
the Intra-day block:After induction under general anesthesia on the day of operation, bupivacaine liposome iliac fascia block was received (within 30 minutes)
Sponsors
Chengdu Second People’s Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Volunteers will be recruited for this trial and must sign a written informed consent form; 2) Patients who have undergone elective surgery for hip fractures, including femoral neck fractures, intertrochanteric fractures, and femoral shaft fractures below the lateral malleolus by at least 5 cm (generally considered the upper third of the femoral shaft) will be eligible; 3) Subjects must be at least 65 years of age (including the lower limit), with no gender restrictions; 4) NRS score must be =4 before surgery; 5) American Society of Anesthesiologists (ASA) physical status classification must be I-III; 6) Subjects must be able to accurately understand the method of pain intensity assessment; 7) 18.0 kg/m2 < BMI < 30.0 kg/m2
Exclusion criteria
Exclusion criteria: 1) Compound injury: combined with multiple fractures, such as head, chest, pelvis, limbs and other parts of the hip trauma; 2) Skin piercing or systemic infection; 3) Past or current mental or neurological disorders such as migraines, anxiety, seizures, and cognitive dysfunction that the investigator believes may interfere with the study evaluator; 4) People who are known to be allergic to amide local anesthetics and opioids; 5) Patients with prior acute or chronic painful physical conditions that the investigators believe may affect the evaluation of postoperative pain; 6) Subjects with high blood risk include subjects with congenital bleeding disorders (such as hemophilia), subjects with thrombocytopenia (platelet counts below 0.75× the lower limit of normal), subjects with abnormal platelet function (such as idiopathic thrombocytopenic purpura, disseminated intravascular coagulation, and thrombocytopenia). Congenital platelet dysfunction), prothrombin time (PT) >ULN+3s, activated partial thromboplastin time (APTT) =ULN+10s; 7) In addition to the drugs permitted by the program, those who have used the following drugs (not more than 5 half-lives of the drug) before randomization: NSAIDs (including compound formulations containing NSAIDs), opioids, narcotics, sedatives, hypnotics, anticonvulsants, antipsychotics, other central nervous system inhibitors and glucocorticoids (other than topical and inhaled drugs); 8) There is nerve injury before fracture, lower limb weakness; 9) Participants who have participated in other drug/device clinical trials and received treatment within 3 months prior to screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Recovery Quality Scale at 24 and 48 hours;NRS score 24 and 48 hours after surgery at rest and coughing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative and postoperative total opioid consumption;Length of stay;Overall patient satisfaction;Adverse effects rate; | — |
Countries
China
Contacts
Public ContactMan Yang
Chengdu Second People’s Hospital
Outcome results
None listed