Non-suici Self-injury
Conditions
Interventions
NSSI non-addiction group:None
NSSI addiction group:None
Healthy control group:None
Sponsors
Hebei Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 18 Years
Inclusion criteria
Inclusion criteria: The subjects included healthy control group, NSSI non-addicted group, and NSSI addicted group. 1. NSSI non-addiction group (1) Meets the diagnostic criteria for NSSI in DSM-V (2) No NSSI addictive characteristics (in the addiction subscale of Ottawa Self-harm Questionnaire, the number of items with a score = 3 is < 3) (3) Age 14-18 years old (4) Understand and be able to sign the informed consent form, and be able to comply with the research arrangement (5) Be able to understand the contents of the questionnaire and cooperate in completing all assessments. 2. NSSI addiction group (1) Meets the diagnostic criteria for NSSI in DSM-V (2) Have NSSI addictive characteristics (the number of items with scores = 3 in the addiction subscale of Ottawa Self-harm Questionnaire is = 3) (3) Age 14-18 years old (4) Understand and be able to sign the informed consent form, and be able to comply with the research arrangement (5) Be able to understand the contents of the questionnaire and cooperate in completing all assessments. 3 Healthy controls: The recruited healthy adolescents were required to match the sex and age with the other two groups. (1) Age 14-18 years old (2) Understand and be able to sign the informed consent form, and be able to comply with the research arrangement (3) Be able to understand the contents of the questionnaire and cooperate in completing all assessments.
Exclusion criteria
Exclusion criteria: The subjects included healthy control group, NSSI non-addicted group, and NSSI addicted group. 1. NSSI non-addiction group (1) Mini interview excludes common mental disorders, personality disorders and mental retardation in axis I (2) Those who have taken oral intestinal microecological preparations, antibiotics, antipsychotics, laxatives, antidiarrheal drugs or weight loss drugs in the last month have used long-acting antipsychotics in the last month; (3) Infections of respiratory tract, digestive tract, urinary tract and other parts in the past month, combined with severe heart, liver, lung, kidney, blood, endocrine, nervous system diseases, autoimmune diseases, malignant tumors and digestive tract operating room, etc.; (4) Patients with irritable bowel syndrome and obesity (body mass index BMI > 28) (5) Strictly vegetarian, vegetarian, severe partial eclipse (6) Current or past substance or drug dependence or abuse (7) All previous self-injury behaviors were aimed at suicide (8) Other researchers think that they are not suitable for enrollment in this experiment, such as pregnancy, the presence of metals in the body, etc. 2. NSSI addiction group (1) Mini interview excludes common mental disorders, personality disorders and mental retardation in axis I (2) Those who have taken oral intestinal microecological preparations, antibiotics, antipsychotics, laxatives, antidiarrheal drugs or weight loss drugs in the last month have used long-acting antipsychotics in the last month; (3) Infections of respiratory tract, digestive tract, urinary tract and other parts in the past month, combined with severe heart, liver, lung, kidney, blood, endocrine, nervous system diseases, autoimmune diseases, malignant tumors and digestive tract operating room, etc.; (4) Patients with irritable bowel syndrome and obesity (body mass index BMI > 28) (5) Strictly vegetarian, vegetarian, severe partial eclipse (6) Current or past substance or drug dependence or abuse (7) All previous self-injury behaviors were aimed at suicide (8) Other researchers think that they are not suitable for enrollment in this experiment, such as pregnancy, the presence of metals in the body, etc. 3 Healthy controls: The recruited healthy adolescents were required to match the sex and age with the other two groups. (1) Conform to the diagnosis of NSSI in DSM-V (2) Past or present mental illness; (3) Previous or present addictive behaviors such as Internet addiction and substance use addiction (4) Have a family history of positive mental illness (5) The remaining exclusion criteria are the same as those of the previous two groups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LC-MS/MS full spectrum metabolome;Microbial diversity;Head MRI plain scan;the blood oxygen level dependent- functional MRI; | — |
Countries
China
Contacts
Public ContactChenyang Gao; Cuixia An
Hebei Provincial People's Hospital; The First Affiliated Hospital of Hebei Medical University
Outcome results
None listed