laparoscopic cholecystectomy
Conditions
Interventions
Group A (control group):Injecting 0.9%NaCl injection with 1ml at bilateral Zusanli points
Group B:Injecting adenosine injection with 0.1mg(1ml) at bilateral Zusanli points
Group C:Injecting adenosine injection with 0.2mg(1ml) at bilateral Zusanli points
Group D:Injecting adenosine with 0.4mg(1ml) at bilateral Zusanli points
Sponsors
Shanghai Fourth People's Hospital affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Patients proposed for laparoscopic cholecystectomy; 3. BMI of 18-30 kg/m^2; 4. ASA classification I to III; 5. Signing of informed consent Voluntarily.
Exclusion criteria
Exclusion criteria: 1. Second or third degree atrioventricular block, sick sinus node syndrome (except patients with artificial pacemakers) ; 2. Patients with pulmonary disease with bronchial stenosis or bronchospasm (such as asthma); 3. Patients with hypersensitivity to adenosine; 4. Persons with communication disorders that prevent them from cooperating with the researcher, such as language comprehension disorders, psychiatric disorders; 5. Those who have had a heart attack or cerebral infarction within six months; 6. Pregnant or lactating women; 7. Infection at the acupuncture point injection site; 8. History of analgesic medication for a continuous period of 3 months prior to enrollment; 9. Other conditions that considered inappropriate for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of first exhaust ;Time of first bowel ;Time of first water intake;Incidence of nausea and vomiting;Blood interleukin-18 concentration at 6h postoperatively;Intraoperative sufentanil and remifentanil dosage;Intraoperative heart rate and mean arterial pressure;Postoperative Pittsburgh Sleep Quality Score ;Complications associated with acupoint injections;Remedial analgesic dosage;Patient Satisfaction Score; | — |
Countries
China
Contacts
Public ContactChen Guozhong
Shanghai Fourth People's Hospital affiliated to Tongji University
Outcome results
None listed