Depression
Conditions
Interventions
Control group :Sertraline hydrochloride tablets 1-2 tablets/day + Sham repeated transcranial magnetic stimulation
Experimental group:Sertraline hydrochloride tablets 1-2 tablets/day+ Repeated transcranial magnetic stimulation
Sponsors
The First Affiliated Hospital of the People's Liberation Army Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 19 Years
Inclusion criteria
Inclusion criteria: Adolescent Major Depressive Disorder with Non-Suicidal Self-Injury (NSSI) Group: 1. Aged 10–19 years; 2. Meets DSM-5 criteria for major depressive disorder; 3. Hamilton Depression Rating Scale-17 (HAMD-17) score >= 17; 4. Meets DSM-5 criteria for non-suicidal self-injury; 5. Adolescent Non-Suicidal Self-Injury Assessment Questionnaire (ANSAQ) score ? 0; 6. No antidepressant treatment of any kind (pharmacological, somatic, or psychological) within the 4 weeks prior to enrollment; 7. Right-handed; 8. After full explanation of rTMS safety, voluntarily agrees to cooperate actively with treatment; Able to comply with the study schedule, complete all procedures, and provide written informed consent together with a legal guardian. Adolescent Major Depressive Disorder with Suicidal Behavior Group: 1. Aged 10–19 years; 2. Meets DSM-5 criteria for major depressive disorder; 3. Hamilton Depression Rating Scale-17 (HAMD-17) score >= 17; 4. History of suicidal behavior; 5. Right-handed; 6. Able to complete the study procedures and provide written informed consent together with a legal guardian.
Exclusion criteria
Exclusion criteria: Adolescent Major Depressive Disorder with Non-Suicidal Self-Injury (NSSI) Group: 1. Organic brain disease; 2. Severe physical illness; 3. Other severe psychiatric disorders; 4. History of epileptic seizures; 5. Implanted devices contraindicated for rTMS (e.g., cardiac pacemaker, artificial valve, cochlear implant, or any other metal implant); current strong suicidal ideation. Adolescent Major Depressive Disorder with Suicidal Behavior Group: 1. Organic brain disease; 2. Severe physical illness; 3. Other severe psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adolescent Non-suicidal Self-injury Assessment ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression ;Hamilton Anxiety;Simplified Coping Style ;Changes in near-infrared brain functional imaging (fNIRS) compared to baseline.;Barratt Impulsiveness ;Pittsburgh Sleep Quality Index;Dimensional Anhedonia Rating ; | — |
Countries
China
Contacts
Public ContactMin Cai
The First Affiliated Hospital of the People's Liberation Army Air Force Military Medical University
Outcome results
None listed