Skin Aging
Conditions
Interventions
Retinol-tolerant group:A half-face control experiment was used, in which subjects applied the 0.15% retinol lotion provided by the company to one side of the face (experimental group), and the retinol
Retinol-intolerant group:Subjects applied the company-supplied 0.25% retinol lotion to half of the face (either the left or right side) at a frequency of once every two days (for 8 days until symptoms
Sponsors
Shenzhen International Graduate School, Tsinghua University
Eligibility
Sex/Gender
Female
Age
22 Years to 38 Years
Inclusion criteria
Inclusion criteria: General Criteria: healthy females, aged 20-40 years old; pass the lactate allergy test; subjects with dull and lifeless complexion; able to cooperate well with the experimenter and maintain regularity of life during the study period; able to read and understand all the contents of the informed consent form and sign it voluntarily; agreeing to refrain from the use of any cosmetic products, medications, and healthcare products during the trial period that would have an effect on the results; and other inclusion criteria as appropriate. Special criteria: (1) Scientific Question 1: Never used a retinol product; demonstrated symptoms of intolerance after initial retinol use. (2) Scientific Question 2: Never used a retinol product; did not show symptoms of intolerance after initial retinol use.
Exclusion criteria
Exclusion criteria: Patients with any of the following conditions must be excluded from the study: facial skin diseases that may affect the judgement of the test results; highly allergic; pregnant, breastfeeding, or intending to become pregnant during the trial period; severe cardiac, hepatic, renal impairment and severe immunocompromise; mental illness, severe endocrine disease, and oral contraceptive pills; participation in drug clinical trials or other tests within 30 days; oral and topical use of beauty products within 2 weeks that may affect the test results; inability to cooperate with the trial; participation in a drug Clinical or other trials within 30 days, or systemic use of drugs that may affect the results of the test within 1 week; oral and topical use of cosmetic products that may affect the results of the test within 2 weeks; inability to co-operate with the test; in the opinion of the investigator, unsuitable for participation in the study; adverse reactions during the test period, which are judged by a dermatologist to be inappropriate to continue to participate in the test; and other appropriate exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Water content of the stratum corneum on cheeks;Transepidermal water loss on cheeks;Skin surface pH;Skin oil content;Facial porphyrin area;Facial pore size;Percentage of skin red zone area;Skin colour Lab values;Number, length, area and volume of wrinkles at the corners of the eyes;Skin microbiome metagenomics sequencing;Skin metabolite Testing; | — |
Countries
China
Contacts
Public ContactLiu Xiao
Tsinghua Shenzhen International Graduate School, Tsinghua University
Outcome results
None listed