Emergence delirium
Conditions
Interventions
(Children's queue) dexmedetomidine group:Preoperative administration of dexmedetomidine nasal spray based on body weight
(Children's queue) midazolam group:Preoperative oral administration of midazolam based on body weight
(Gynecological queue) Dexmedetomidine group:Preoperative administration of 100ug of dexmedetomidine nasal spray
(Gynecological queue) midazolam group:Preoperative intravenous administration of midazolam 0.05mg/kg
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 70 Years
Inclusion criteria
Inclusion criteria: Child queue: 1. Age 3-6 years old; 2. ASA grades I-II; 3. No dysfunction of neuromuscular conduction and nasopharyngeal diseases; 4. Accept tonsillectomy and/or adenoidectomy surgery. Gynecological queue: 1. Age range of 18 to 70 years old; 2. Patients planning to undergo laparoscopic total hysterectomy surgery; 3. ASA grades I-II; 4. BMI: 18.5~24kg/m^2.
Exclusion criteria
Exclusion criteria: Children's queue: 1. Individuals allergic to benzodiazepines and dexmedetomidine drugs; 2. Delayed development; 3. Suffering from congenital diseases such as megacolon, congenital heart disease, etc; 4. Severe heart, lung, liver, and kidney dysfunction; 5. Children with neurological disorders; 6. Psychological disorders in children with psychological disorders (including behavioral disorders, emotional disorders, hyperactivity syndrome, autism, and developmental delays, etc.); 7. Children with severe anemia (Hct=30; 11. Children who have already started primary school; 12. The patient is currently participating in other studies; 13. Parents refuse to participate. Gynecological queue: 1. Individuals allergic to benzodiazepines and dexmedetomidine drugs; 2. Patients with severe underlying diseases such as heart, lung, liver, and kidney; 3. Long term use of analgesics or sedatives before surgery; 4. Patients with bradycardia and atrioventricular block; 5. Patients with severe nasal diseases that are not conducive to drug absorption; 6. Patients with angle closure glaucoma; 7. Preoperative MMSE scores are less than 17 for illiterate patients, less than 20 for patients with primary school education, and less than 24 for patients with secondary school or higher education; 8. Participating in other trials; 9. The researchers believe that it is not appropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate;Incidence of emergence delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of emergence agitation;Incidence of emergence pain;Perioperative respiratory adverse event;Induction Compliance;Post Hospitalization Behavior;Qor-15; | — |
Countries
China
Contacts
Public ContactGao jingui
The Second Hospital of Hebei Medical University
Outcome results
None listed