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Effect of a single low-dose dose of esketamine on postpartum depression and quality of recovery in women undergoing cesarean section: a prospective, randomised controlled study

Effect of a single low-dose dose of esketamine on postpartum depression and quality of recovery in women undergoing cesarean section: a prospective, randomised controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088992
Enrollment
Unknown
Registered
2024-08-30
Start date
2024-09-01
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Ketamine group:The ketamine group received intravenous infusion of 0.2mg/kg ketamine after cesarean section for 40 minutes
Physiological saline group:Intravenous infusion of physiological saline after cesarean section for 40 minutes.

Sponsors

Dongguan Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria 1. ASA classification I-II; Full term singleton mothers 2. Age range of 18 to 60 years old; 3. Body mass index (BMI) 18~35kg/m2; 4. Patients undergoing elective cesarean section with a surgical duration of less than 2 hours; 5. Capable of signing informed consent forms and willing to accept relevant treatment plans

Exclusion criteria

Exclusion criteria: 1. Individuals with contraindications for intraspinal puncture; Failure of spinal anesthesia; 2. History of long-term use of analgesics, sedatives, and anti anxiety drugs; 3. Hypertension, diabetes, hyperthyroidism, hypothyroidism, etc. before pregnancy; 4. Known individuals who are allergic to the experimental drug 5. Patients with communication barriers, cognitive impairment, and a history of mental illness; 6. There are other situations where researchers believe it is not appropriate to participate in this study

Design outcomes

Primary

MeasureTime frame
Edinburgh Postnatal Depression Scale (EPDS) scores on the 2nd and 7th day postpartum;

Secondary

MeasureTime frame
Postpartum Recovery Quality Score (ObsQoR-10) at 24 and 48 hours postpartum;Resting and exercise pain score (VAS) 24 hours postpartum;Postpartum hospitalization duration;

Countries

China

Contacts

Public ContactTu Yuanyan

Dongguan Maternal and Child Health Hospital

jxtuyuan@sina.com+86 137 2999 0829

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026