Chronic Hepatitis B
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. HBsAg and HBeAg positive; 2. All patients had not used interferon antiviral therapy before enrollment. 3. The diagnosis met the diagnostic criteria of the 2022 revised Guidelines for the prevention and treatment of chronic hepatitis B. 4. Voluntarily cooperate to complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or planned pregnancy in the near future; 2. Underlying diseases such as psychiatric history (schizophrenia or severe depression), uncontrolled epilepsy, unabstinent alcohol/drug addict, uncontrolled autoimmune disease, decompensated liver cirrhosis, thyroid disease, severe infection, retinal disease, heart failure, chronic obstructive pneumonia, etc. 3. Neutrophil count < 1.0×10^9/L and platelet count < 50×10^9/L before treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum HBV RNA load (Absolute decrease; clearance rate; seroconversion rate);Serum HBcrAg load (Absolute decrease; clearance rate; seroconversion rate);Serum HBsAg levels (Absolute decrease; clearance rate; seroconversion rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum ALT levels; | — |
Countries
China
Contacts
Public ContactEnqiang Chen
West China Hospital of Sichuan University
Outcome results
None listed