Gastric disease
Conditions
Interventions
group C:Initially, administer 5 mL of NS followed by ciprofol at a dosage of 0.4 mg/kg, with additional propofol provided as needed.
group CE1:Initially, administer esketamine at a dosage of 0.15 mg/kg followed by ciprofol at 0.4 mg/kg, with additional propofol provided as needed.
group CE2:Initially, administer esketamine at a dosage of 0.25 mg/kg followed by ciprofol at 0.4 mg/kg, with additional propofol provided as needed.
group CE3:Initially, administer esketamine at a dosage of 0.35 mg/kg followed by ciprofol at 0.4 mg/kg, with additional propofol provided as needed.
Sponsors
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Eligible patients for gastrointestinal endoscopy are those aged between 18 and 65 years, with no gender restrictions, a body mass index (BMI) ranging from 18 to 28 kg/m², and an American Society of Anesthesiologists (ASA) physical status classification of I or II.
Exclusion criteria
Exclusion criteria: Patients with severe cardiopulmonary diseases, neurological or psychiatric disorders, those who have taken analgesics within 48 hours prior to surgery, or those with a history of allergy to esketamine or propofol are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP;HR;RR;SPO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of ciprofol;awakening time;Discharge time;Patient satisfaction;Incidence of cardiopulmonary complications;Incidence of other adverse reactions; | — |
Countries
China
Contacts
Public ContactJiarui Zou
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Outcome results
None listed