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A study on the perioperative effect of bupivacaine combined with different doses of hydromorphone under single spinal anesthesia in patients undergoing cesarean section

A study on the perioperative effect of bupivacaine combined with different doses of hydromorphone under single spinal anesthesia in patients undergoing cesarean section

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088968
Enrollment
Unknown
Registered
2024-08-29
Start date
2024-04-17
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nothing

Interventions

Group A:A single dose of spinal anesthesia was performed using the direct puncture method through the midline approach. After successful puncture, a mixture of 0.5% bupivacaine 7.5mg (Shanghai Chaohui
Group B:A single dose of spinal anesthesia was performed using the direct puncture method through the midline approach. After successful puncture, a mixture of 0.5% bupivacaine 7.5mg (Shanghai Chaohui
Group C:Group C parturients were placed in a left lateral position and subjected to combined spinal and epidural anesthesia using a traditional internal needle method (25G spinal anesthesia needle).

Sponsors

Ganzhou People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 38 Years

Inclusion criteria

Inclusion criteria: 1. Patients with good mental state and no communication barriers, second cesarean section, placental implantation or placenta previa; 2. Patients and their families voluntarily sign informed consent forms; 3. No history of allergies to opioid and amide local anesthetics

Exclusion criteria

Exclusion criteria: 1. psychosis, diabetes, accompanied with neurological diseases; 2. Contraindications for spinal anesthesia such as infection and coagulation dysfunction at the puncture site 3. Complete placenta previa and emergency events such as rescue during surgery; 4. Long term use of analgesic drugs; 5. Patients with severe heart, liver, kidney and other functional impairments and a history of bleeding tendency; 6. Patients who withdrew from the study midway or did not complete relevant data follow-up statistics, as well as other situations that are not suitable for this study.

Design outcomes

Secondary

MeasureTime frame
Surgical time;Bleeding volume;PCA frequency;Infusion volume; 25/10000 25/1000015Apgar Apgar score at 1 min and 5 min of newborn birth;

Primary

MeasureTime frame
The occurrence of adverse reactions such as nausea and vomiting, chest tightness, dyspnea, chills, skin itching, urinary retention, and back discomfort during the operation;;HR, BP, Sp02 during patient anesthesia;The highest anesthesia level for spinal anesthesia.;Incidence of hypotension in patients;Addition frequency of ephedrine;Changes in VAS scores during intraoperative laparotomy (T2), fetal delivery (T3), and suturing (T4);;VAS scores for pain during rest, exercise, and peak pain at 6 hours (T6) and 12 hours (T7) after surgery;;

Countries

China

Contacts

Public ContactWeibo Zhong

Ganzhou People's Hospital

1016824534@qq.com+86 187 7905 6260

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026