Recurrent Aphthous Ulcer
Conditions
Interventions
The experimental group:Using toothpaste containing honeysuckle extract (fermented by probiotics)
The control group:Using toothpaste without honeysuckle extract (all other ingredients are the same except for honeysuckle extract)
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Good overall health status with no significant systemic diseases; (2) Aged 20 to 60 years; (3) If female, not pregnant or breastfeeding; (4) Diagnosed with recurrent aphthous ulcers with an onset within the past 48 hours and no previous treatment; (5) Provide informed consent and be able to complete clinical trials as required.
Exclusion criteria
Exclusion criteria: (1) Allergies to the investigational toothpaste ingredients; (2) Individuals who have used analgesics or vitamins within 24 hours, antibiotics within 1 month, and systemic corticosteroids or immunomodulators within 3 months prior to participating in the study; (3) Severe aphthous ulcers, herpetic aphthous ulcers, acute herpetic gingivostomatitis, traumatic ulcers, cancerous ulcers, tuberculous ulcers, syphilitic ulcers, necrotizing sialometaplasia, Behçet's disease, and ulcers caused by other diseases or medications; (4) Suspected or confirmed history of alcohol or drug abuse; (5) Individuals currently participating in or planning to participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of ulcer status ;Ulcer healing rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ulcer number score ;Ulcer size score ;Ulcer hyperemia score ;Ulcer pain score;Ulcer burning sensation score ;Average ulcer duration score; | — |
Countries
China
Contacts
Public ContactJijia Li
Xiangya Hospital, Central South University
Outcome results
None listed