depression
Conditions
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 85 Years
Inclusion criteria
Inclusion criteria: Age between 13 and 85 years, regardless of gender; Meeting the diagnostic criteria for major depressive episode as outlined in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), including major depressive disorder, bipolar I disorder, and bipolar II disorder; Scoring =17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); Having a stable medication regimen for the past 4 weeks prior to enrollment; Not having received transcranial magnetic stimulation, transcranial electrical stimulation, or electroconvulsive therapy within the last 6 months; Having sufficient auditory and visual abilities to complete the necessary assessments required for the study; Agreeing to participate in the study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Meeting any other diagnostic criteria outlined in DSM-5; High suicide risk: currently having suicidal thoughts or plans, scoring 3 or 4 on the suicide item of the HAMD-17 scale, or being judged by the researcher to have a high suicide risk; Hypothyroidism or major physical illnesses such as heart, liver, or kidney diseases that render the individual unable to tolerate the study; Neurological diseases such as central nervous system infections, stroke, hydrocephalus, brain tumors, or epilepsy; History of epileptiform discharges confirmed by electroencephalography (EEG); Current use of anticonvulsant medications; Currently undergoing psychotherapy; Having contraindications for MRI examination, such as having a pacemaker implanted or an arterial clip retained after craniocerebral surgery; Having ferromagnetic materials inside the body, such as retained metal foreign bodies, artificial metal valves after heart surgery; Having metal prostheses, metal joint replacements, insulin pumps, or neurostimulators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-HAMD;EEG; | — |
Countries
China
Contacts
Public Contactxiaomei zhong
The Affiliated Brain Hospital of Guangzhou Medical U
Outcome results
None listed