urothelial carcinoma
Conditions
Interventions
Group 1 18F/68Ga-SMIC-4200 PET:18F/68Ga-SMIC-4200 iv
Sponsors
Shanghai 10th People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria: (1) urothelial carcinoma was pathologically diagnosed; (2) Locally advanced urothelial carcinoma or metastatic urothelial carcinoma. Inclusion criteria: 1) Meet the above diagnostic criteria; 2) Age >18 years old; 3) HER2 targeted drug therapy is proposed; 4) Male and female sex is not limited.
Exclusion criteria
Exclusion criteria: (1) Under 18 years of age; (2) The pathological diagnosis of HER2 in the primary lesion could not be obtained; (3) Patients who do not want to participate in the study or do not want to sign informed consent; (4) Critically ill patients, suffering from mental diseases, can not cooperate with the examination of patients; (5) Pregnant and lactating women; (6) Severe heart diseases such as heart obstruction, heart failure, and unstable angina within 3 months; (7) Severely impaired liver function (AST or ALT> 4 times the upper limit of normal); (8) Renal insufficiency (BUN or CR> 2 times the upper limit of normal); (9) Embolic diseases such as venous thrombosis or pulmonary embolism; (10) Infectious diseases such as urinary system infection, respiratory system infection; (11) Have been or are receiving HER2-targeted drug therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total volume of HER/FDG2 positive tumor;The SUVmax of HER/FDG2 positive tumor ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change of SUVmax of HER/FDG positive tumor before and after treatment; | — |
Countries
China
Contacts
Public ContactMA CHAO
Shanghai 10th People's Hospital
Outcome results
None listed