Acute ischemic stroke
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over; 2. The time of arrival at the hospital is not more than 24 hours from the onset of stroke or the last normal time; 3. Clinical diagnosis of AIS due to anterior/posterior circulation large vessel occlusion on DSA/CTA/MRA; 4. Alberta Stroke Program Early CT Score (ASPECTS) = 3; 6. Informed consent obtained from patients or their legal representatives. .
Exclusion criteria
Exclusion criteria: 1.Confirmed intracranial hemorrhage through computed tomography (CT) or magnetic resonance imaging (MRI); 2.Pre-stroke modified Rankin Scale (mRS) score >= 2; 3.Pregnancy or breastfeeding women; 4.Genetic or acquired bleeding diathesis, deficiency of anticoagulant factors, or use of anticoagulant medication with an International Normalized Ratio (INR) > 3; 5.Presence of intracranial tumors with mass effect on imaging (excluding small meningiomas); 6.Any end-stage disease with expected survival less than 6 months; 7.Anticipated inability to complete follow-up; 8.Brain herniation causing midline shift; 9.Presence of severe complications that may affect patient prognosis and follow-up (cancer, severe heart failure, renal failure); 10. Suspected septic embolism or bacterial endocarditis; 11. Participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of 90-day modified Rankin scale (mRS) score 0-2(%);The rate of symptomatic intracerebral hemorrhage (SICH) at 48-hour and death at 90-day; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of 90-day modified Rankin scale (mRS) score 0-3(%);The rate of 90-day modified Rankin scale (mRS) score 0-1(%);Shift in the distribution of mRS scores at 90 days;EQ-5D score at 90 days;The rate of any type of intracranial hemorrhage at 48-hour;The rate of death at 7-day; | — |
Countries
China
Contacts
Public ContactZi Wenjie
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed