Post-induction hypotension
Conditions
Interventions
1:Induction dose: Propofol 0.3mg/kg
Maintenance dose: Propofol 0.8mg/kg ·
2:Induction dose: Ciprofol 0.3mg/kg
Maintenance dose: Ciprofol 0.8mg/kg ·
Sponsors
The Traditional Chinese Medicine Hospital of Kunshan
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age= 60 years old (2) Use a non-invasive continuous arterial blood pressure monitoring system and (3) elective non-cardiac surgery planned under general anesthesia (4) ASA Grading I.~IV. (4) Modified vulnerability index MFI=3 (5) Postoperative planned extubation (6) Informed consent, voluntarily participate in the trial, and sign the informed consent form
Exclusion criteria
Exclusion criteria: (1) Use regional anesthesia (2) Severe liver disease (3) Chronic kidney disease requiring dialysis (4) Gastroesophageal reflux disease (5) Obstructive sleep apnea (6) History of drug dependence (7) Neurological diseases (8) Systolic blood pressure = 180mmHg and/or diastolic blood pressure = 100mmHg at screening (9) Systolic blood pressure < 90mmHg at screening (10) Subjects who are considered inappropriate by the investigator to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bispectral Idex during the period from skin incision to the last skin suture; | — |
Secondary
| Measure | Time frame |
|---|---|
| rate of hypotension after induction;Delirium Screening Scale;Time to loss of eyelid reflex;Time to loss of consciousness after anesthesia induction;Time to tracheal extubation;Time to recovery of consciousness from tracheal extubation;Cardiac output;Stroke variability;Peripheral vascular resistance;Oxygen supply index;Oxygen consumption index;Postoperative delirium-associated serum biomarkers;Modified Aldrete score;Brice questionnaire;rate of adverse events; | — |
Countries
China
Contacts
Public ContactQiao Shigang
Department of Anesthesiology, The Traditional Chinese Medicine Hospital of Kunshan
Outcome results
None listed