coronary artery disease
Conditions
Interventions
A:Sotalol
B:Metoprolol
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients who are willing to participate in this study and can sign the informed consent form (=18 years old on the day of surgery). 2. Patients scheduled for elective isolated coronary artery bypass grafting surgery (without valve surgery). 3. Patients with sinus rhythm and no history of atrial fibrillation (including permanent atrial fibrillation, persistent atrial fibrillation, paroxysmal atrial fibrillation, and initial atrial fibrillation), and who do not need to use antiarrhythmic drugs (except beta-blockers) during surgery.
Exclusion criteria
Exclusion criteria: 1. Sinus bradycardia (heart rate 450 milliseconds, congenital or acquired long QT syndrome and history of torsade de pointes. 4. Incorrigible hypokalemia (<3.5 mmol/L), hypomagnesemia <0.75 mmol/L. 5. Acute myocardial infarction (occurring within two months), clinically uncontrolled heart failure (EF <40%), infective endocarditis, active pericarditis or myocarditis. 6. Bronchial asthma, severe obstructive pulmonary disease or other contraindications to beta-blocker therapy. 7. Creatinine clearance rate <40 ml/min. 8. Use of antiarrhythmic drug therapy (except beta-adrenergic receptor blockers). 8. History of drug allergy and serious adverse reactions to sotalol and metoprolol. 9. In any blood pressure measurement during preoperative hospitalization, systolic blood pressure <100 mmHg, or preoperative need for intravenous pumping of positive vasoactive drugs (such as dopamine, norepinephrine, epinephrine, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative atrial fibrillation; | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause death;cardiovascular-related death;stroke;post-operative length of stay;post-operative length of ICU stay;in-hospital cost; | — |
Countries
China
Contacts
Public ContactChenfei Rao
Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed