Colorectal Cancer
Conditions
Interventions
Group A:Induction with 0.8mg/kg esketamine administered intranasally in combination with endotracheal intubation for general anesthesia.
Group B:Induction with 0.4mg/kg esketamine administered intravenously in combination with endotracheal intubation for general anesthesia.
Group C:Induction with an equivalent volume of saline administered intravenously in combination with endotracheal intubation for general anesthesia.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective colorectal cancer surgery in our hospital; 2. ASA classification I-III; 3. Normal communication and ability to understand instructions; 4. Expected postoperative stay without ICU admission; 5. Willingness to participate in the study and signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe respiratory or circulatory system diseases such as severe coronary artery disease, chronic obstructive pulmonary disease, etc.; 2. Contraindications to ketamine such as glaucoma, large vessel arterial aneurysm, etc.; 3. Functional impairments that prevent accurate participation in postoperative pain assessment; 4. Severe endocrine system diseases such as pituitary tumors, severe diabetes, etc.; 5. Mental health disorders such as schizophrenia, depression, epilepsy, history of chronic analgesic use, history of alcohol abuse, opioid dependence, etc.; 6. Inability to cooperate with the researchers for any reason, such as hearing or visual impairment, language comprehension difficulties, etc.; 7. History of Parkinson’s disease, stroke, Alzheimer’s disease, insomnia, severe hepatic dysfunction (Child C), renal dysfunction (preoperative dialysis), etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 15 recovery quality scores at 24 hours after surgery ; | — |
Secondary
| Measure | Time frame |
|---|---|
| 15 recovery quality scores at 48,72 hours after surgery ;Postoperative 24h, 48h, 72h Richards-Campbell Sleep Questionnaire scores ;Intraoperative and Critical Care Fatigue Score-10 ;VAS grade ;The intraoperative hemodynamics ;The dose of anesthetic drugs used ;Postoperative first bowel gas passage time ;Delirium Incidence Rate ;Frequency of Nausea and Vomiting ; | — |
Countries
China
Contacts
Public ContactGuanghong Xu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed