rosacea
Conditions
Interventions
A:Phase 1 (0-8 weeks) : fish oil treatmentl
Phase 2 after enrollment (weeks 8-16) : placebo
B:Phase 1 after enrollment (weeks 0-8) : Placebo
Phase 2 (8-16 weeks) : fish oil treatment
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? 18-65 years old, male or female; ? patients with mild-to-moderate erythema telangiectasia rosacea diagnosed by a dermatologist (CEA score 1-3); ? patients with mild papulopustular rosacea diagnosed by dermatologists (IGA score 1-2); ? sign informed consent form voluntarily
Exclusion criteria
Exclusion criteria: ? women who are pregnant and lactating or who are planning a recent pregnancy ? patients with diabetes mellitus, moderate to severe liver, kidney, lung, blood and other systemic diseases, mental disorders ? Rosacea patients with nasal hypertrophy ? digestive and absorption dysfunction (achorhydria, acute or chronic gastrointestinal ulcer or duodenal surgery) 5) Allergies to seafood ? Long-term self-supplementation of fish oil (can be included after a washout period of more than 8w) ? Oral monoamine oxidase inhibitors (such as phenelzine, seligiline) ? Facial manifestations associated with other facial skin diseases, such as dermatomyositis or systemic lupus erythematosus ? Patients who are not expected to adhere to follow-up ? who participated in any clinical trial within one month ?Other circumstances considered by the investigator to be ineligible for inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CEA score; | — |
Secondary
| Measure | Time frame |
|---|---|
| IGA score;Rosacea Patient Quality of Life Scale;Anxiety and depression rating scale;Dermoscopy;Transconfocal microscopy (RCM) was used for examination;Facial VISIA;Assessment of skin barrier function; | — |
Countries
China
Contacts
Public ContactPeiru Wang
Shanghai Skin Disease Hospital
Outcome results
None listed