Lung cancer
Conditions
Interventions
Test group:Using the contralateral esophagus-sparing technique (CEST) in radiotherapy planning
Control group:Adopting the conventional esophageal dose constraints based on RTOG standards
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 to 85 years old; 2) Small cell lung cancer confirmed by histology or cytology; 3) confirmed limited stage (stage I-III, according to the 8th edition of AJCC); 4) Must have tumor lesions (including primary tumor or involved lymph nodes) within 1 cm of the esophagus on recent CT images; 5) Must have adequate organs function; 6) Females of childbearing potential must undergo a serum pregnancy test before the start of radiotherapy, and the result is negative; 7) ECOG PS 0-1; expected survival period = 12 weeks; 8) The subjects voluntarily joined the study and signed the informed consent form. They had good compliance and cooperated with the follow-up.
Exclusion criteria
Exclusion criteria: 1) With a history of tumor that has received thoracic radiotherapy in the past; 2) Tumors suspected or known to invade the esophagus; 3) Previously diagnosed with reflux esophagitis and not completely relieved; 4) Complicated with other diseases such as cardiovascular, urinary, digestive, hematopoietic, endocrine and metabolic systems, etc., with serious complications, liver and kidney insufficiency, and mental illness; 5) Patients who are pregnant or lactating women; 6) Patients who do not follow the doctor's advice, could not judge the curative effect or with incomplete clinical data which would affect the judgment of curative effect; 7) Patients with poor complications or unable to cooperate as judged by the doctor; 8) Researchers consider as not appropriate to participate in; 9) Patients refused to sign the informed consent form after a specific explanation; 10) With a history of allergic reactions to the chemotherapy drugs used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe esophagitis incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective Response Rate;Disease Control Rate;Overall survival; | — |
Countries
China
Contacts
Public ContactYaping Xu, Hui Liu
Shanghai Pulmonary Hospital
Outcome results
None listed