Haemorrhoidectomy
Conditions
Interventions
Retrospective cohort:none
Prospective cohort:none
Sponsors
Nanjing Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Prospective cohort: 1. Voluntarily sign informed consent; 2. Patients with mixed hemorrhoids undergoing elective hemorrhoidectomy; 3. Age =18 years old; 4. American Society of Anesthesiologists (ASA) grade ?~?. Retrospective cohort: 1. Patients with mixed hemorrhoids undergoing hemorrhoidectomy; 2. Use of bupivacaine liposome injection or other analgesic regimens for postoperative acute pain; 3. Age =18 years old, regardless of gender.
Exclusion criteria
Exclusion criteria: Prospective cohort: 1. Patients with comorbid mental disorders and cognitive impairment; 2. Patients with sensory disorders such as hyperalgesia, or other bodily pain affecting postoperative pain assessment; 3. The history of myocardial infarction, unstable angina pectoris, or severe arrhythmia (such as atrioventricular block of degree ? or above) within 6 months; 4. Patients with diabetic peripheral neuropathy; 5. Abnormal liver function: aspartate aminotransferase (AST) or/and alanine aminotransferase (ALT) and/or total bilirubin (TBIL) =1.5×ULN; 6. Known to be allergic to bupivacaine or other amide local anesthetics; 7. Pregnant and lactating women; 8. Patients with any other factor considered by the investigator to be ineligible for the trial. Retrospective cohort: 1. Patients with concurrent pain in other parts of the body other than the surgical site, or patients with chronic pain; 2. Patients with missing data information related to key studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with NRS score =3 at rest within 72 hours after the end of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores in resting/active state within 72 hours after surgery were recorded;Maximum pain intensity score during each defecation change within 3 days after surgery;Maximum pain intensity score during each dressing change within 3 days after surgery;Opioid consumption (as intravenous morphine equivalent) within 72 hours after the end of surgery;Time to first receipt of rescue analgesic within 72 hours after the end of surgery;Number of rescue analgesic administered within 72 hours after the end of surgery;The Quality of Recovery scale (QoR-15) was used to evaluate the quality of recovery at 24h and 72h after operation;Length of Stay;Opioid consumption (as intravenous morphine equivalent) within 72 hours after the end of surgery; | — |
Countries
China
Contacts
Public ContactYang Zhang
Nanjing Traditional Chinese Medicine Hospital
Outcome results
None listed