Aplastic anemia
Conditions
Interventions
The group of Mini-ATG:To carry out allogeneic umbilical cord blood stem cell transplantation with miniATG+TBI+FLU+CTX as conditioning regimen for the treatment of acquired anemia
Sponsors
Institute of Hematology, Blood Disease Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 years both male and female 2) Bone marrow morphology and biopsy confirmed acquired aplastic anemia with indication for HSCT 3) ECOG score = 2 4) Informed consent of the children legal guardian. Eligible children in this study were required to meet the above 4 criteria Eligible children in this study were required to meet the above 4 criteria.
Exclusion criteria
Exclusion criteria: 1) Severe organ dysfunction or disease 2) HIV-positive, active hepatitis Bactive hepatitisC or active tuberculosis with other potentially life-threatening serious infections 3) Congenital bone marrow failure syndromes 4) PNH cloning 5) Myelodysplastic syndrome 6) Any other conditions recognized by the researchers as unsuitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| acute GVHD rate;engraftment rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil engraftment time;platelet engraftment time;graft failure rate;chronic GVHD rate;overall survival time;disease-free survival time;event-free survival time; | — |
Countries
China
Contacts
Public ContactZhu Xiaofan
Institute of Hematology, Blood Disease Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed