schizophrenia
Conditions
Interventions
Experimental group for patients:Repetive Transcranial Magnetic Stimulation Therapy
Control group for patients:Pseudo-stimulation Therapy
Healthy control group:NA
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for SCZ patients were as follows: (1) Han nationality, male or female, aged 18 to 55 years; (2) right-handed according to the handedness questionnaire; (3) meeting the clinical diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5); (4) education level = 9 years, no language communication barriers, and able to cooperate with assessment and treatment; (5) written informed consent was obtained from the patient. If the patient was incapable of acting during the onset period, written informed consent from his or her legal guardian was required. The inclusion criteria for healthy subjects were as follows: (1) Han nationality, aged 18 to 55 years; (2) right-handed according to the handedness questionnaire; (3) education years = 9 years.
Exclusion criteria
Exclusion criteria: Exclusion criteria for SCZ patients included: (1) patients who met the DSM-5 diagnostic criteria for schizoaffective disorder, depressive disorder, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, memory impairment or other cognitive impairment; (2) patients with severe unstable physical illness, organic brain disease (such as ischemic stroke, cerebral hemorrhage, brain tumor, etc.) or history of severe brain trauma, narrow-angle glaucoma; (3) patients with a history of alcohol or substance abuse/dependence in the past year; (4) patients with a history of epilepsy (at least 2 unprovoked epileptic seizures with an interval of more than 24 hours, or a diagnosis of epilepsy syndrome, or epileptic seizures in the past 12 months) or febrile convulsions; (5) patients with a history of loss of consciousness for more than 5 minutes; (6) patients with a history of suicide attempts, serious suicidal thoughts/behaviors or risk of harming others; (7) patients who had received electroconvulsive therapy (ECT) or rTMS in the past 3 months; (8) pregnant or breastfeeding women, or those planning to become pregnant; (9) Patients with pacemakers, cochlear implants or other metal foreign bodies and any electronic devices implanted in the body, or patients with contraindications to MRI such as claustrophobia; (10) Patients with contraindications to rTMS treatment such as those who cannot tolerate magnetic stimulation or have skin ulcers at the treatment site; (11) Patients with a history of epilepsy (at least 2 uninduced epileptic seizures with an interval of more than 24 hours, or diagnosed with epilepsy syndrome, or epileptic seizures in the past 12 months); (12) Patients currently participating in clinical trials of other drugs or physical therapies (such as deep brain stimulation, electroconvulsive therapy, rTMS); (13) Patients deemed unsuitable by researchers. Exclusion criteria for healthy subjects included: (1) the individual or first-degree relatives had any mental disorder that met the diagnostic criteria of DSM-5; (2) had severe unstable physical illness, organic brain disease (such as ischemic stroke, cerebral hemorrhage, brain tumor, etc.) or history of severe brain trauma, narrow-angle glaucoma; (3) had a history of alcoholic substance abuse/dependence in the past year; (4) had a history of epilepsy (at least 2 unprovoked epileptic seizures with an interval of more than 24 hours, or diagnosed with epilepsy syndrome, or had epileptic seizures in the past 12 months), or febrile convulsions; (5) had a history of loss of consciousness for more than 5 minutes; (6) had a history of suicide attempts, serious suicidal thoughts or behaviors; (7) were pregnant or breastfeeding women, or were planning to become pregnant; (8) had a pacemaker, cochlear implant, or other metal foreign body, or any electronic device implanted in the body, or had contraindications to MRI scanning such as claustrophobia; (9) were considered unsuitable for participation by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale;Personal and Social Performance Scal;Clinical Global Impression- Improvement;Treatment Emergent Symptom Scale; | — |
Countries
China
Contacts
Public ContactYuyanan Zhang
Peking University Sixth Hospital
Outcome results
None listed