Oral candidiasis
Conditions
Interventions
Experimental group:methylene blue photodynamic therapy
Control group:Nystatin tablets
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Any gender, age >18 years; 2. Clinically diagnosed with oral candida infection; 3. Positive for fungal smear by microscopy or positive for saliva fungal cultures; 4. Female participants of childbearing age in the study with negative pregnancy tests and voluntarily using contraception throughout the course of the trial; 5. Participants in the study voluntarily enroll and a written informed consent form is signed.
Exclusion criteria
Exclusion criteria: 1. Clinically confirmed with other systemic mycoses; 2. Those with a known history of allergy to the test drug, who cannot tolerate it, or who are themselves allergic individuals; 3. Women who are pregnant or breastfeeding; 4. Those who have mental illnesses that prevent them from cooperating well and from evaluating changes regularly; 5. Individuals with hepatic insufficiency (ALT, AST, or TBIL > 1.5 times the upper limit of normal reference values), or clinical manifestations of hepatic disease in the two months prior to the implementation of the study; 6. Those with renal insufficiency (CR > 1.5 times upper limit of normal reference value); 7. Individuals with cardiac insufficiency (e.g., those with ischemic heart failure or a history of congestive heart failure); 8. Those with hematopoietic disorders; 9. Those who have received other systemic antifungal medications within 30 days or topical antifungal medications within 2 weeks prior to the consultation; 10. Those with chronic cutaneous mucocutaneous candidiasis (CMCC); 11. Patients who are HIV-positive; 12. Patients with clinically proven diseases affecting oral salivary secretion or taking medications that affect salivary secretion; 13. Those who have participated in other clinical trials within the last month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral pain/burning sensation grading;Mucosal atrophy/erythema grading;Fungal examination; | — |
Countries
China
Contacts
Public ContactPeiru Zhou
Peking University Hospital of Stomatology
Outcome results
None listed