Incidence of hypotension during surgery
Conditions
Interventions
Esketamine group:0.15 mg kg - 1 esketamine was injected intravenously after 0.75% ropivacaine 10ml was injected through an epidural catheter
Matched group:0.9% sodium chloride injection of equal volume was injected intravenously after 0.75% ropivacaine 10ml was injected through an epidural catheter
Sponsors
Guiyang maternal and child health care hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1)Single pregnancy full-term pregnancy cesarean section; (2)American Society of Anesthesiologists (ASA) Grade I to II (3)Women of childbearing age over 18 years old, gestational age is greater than or equal to 37 weeks (4)BMI 18~40kg/m2; (5)There are no contraindications to intraspinal anesthesia (6)Volunteer for the study and obtain informed consent
Exclusion criteria
Exclusion criteria: exclusion criteria:(1)Known allergy to esketamine;(2) Persons with mental illness or cognitive impairment who are unable to perform relevant assessments;(3)Fetal distress or abnormality, placenta previa, placental abruption. Exclusion criteria:(1) After entering the operating room, the patient had two resting periods in the supine position with SBP>140 mmHg or SBP<90mmHg; (2) The amount of blood lost during the operation exceeds 15% of the total maternal blood volume; (3) The dural membrane was accidentally punctured, the catheter was placed in the blood vessel or the subarachnoid space; (4) Patients with poor epidural anesthesia effect who need to change the anesthesia program; (5) A serious condition has occurred that may require treatment; (6) Situations in which the investigator believes that termination of the study would be beneficial to the maternal health.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of VAS;sedation score;Neonatal Apgar score; | — |
Countries
Chnia
Contacts
Public Contactzhangxingwei
Guiyang maternal and child health care hospital
Outcome results
None listed