Aortic disease
Conditions
Interventions
Experimental group:After induction of anesthesia and after aortic opening, remote ischemic preconditioning and posttreatment were performed respectively: the cuff was placed on the patients right uppe
Control group:Remote ischemia treatment was performed after anesthesia induction and after aortic opening respectively: the cuff was placed on the patients right upper limb, and 5 minutes of ischemia
Sponsors
Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Over 18 years of age; 2) Patients undergoing elective or emergency aortic surgery; 3) Sign a written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1) Under 18 years of age; 2) Symptomatic upper limb atherosclerosis, previous upper limb venous thrombosis, or history of axillary vascular surgery; 3) lactation or pregnancy; 4) Cardiac arrest on admission; 5) Severe liver dysfunction (international normalized ratio > 2); 6) History of malignant tumor; 7) Severe lung disease (predicted forced expiratory volume < 40% in 1 second), preoperative respiratory infection; 8) Previous renal failure, history of renal transplantation, and preoperative estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2; 9) Take glibenclamide or nicordil, as these drugs may interfere with RIPC; 10) Previous cerebral infarction, residual limb movement disorder, brain trauma, neurosurgery history 11) History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis or dementia; 12) Being recruited into another study that could affect this study; 13) Those with other conditions deemed unsuitable for inclusion by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality during hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Myocardial infarction;Neurocognitive dysfunction;Pulmonary infection;Acute kidney injury;Mechanical circulation aid; | — |
Countries
China
Contacts
Public ContactChunmei Xie
Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed