Liver transplantation, kidney transplantation
Conditions
Interventions
test group-kidney transplantation:sirolimus
test group-liver transplantation:sirolimus
control group-kidney transplantation:adjust immnosuppressive regimen without adding sirolimus
control group-liver transplantation:adjust immnosuppressive regimen without adding sirolimus
Sponsors
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-75 adult male and female 2. First time to receive liver transplantation or kidney transplantation 3. For kidney transplantation, Creatinine > 133mmol/L 4. For liver transplantation, Creatinine > upper limit of normal 5. No history of sirolimus 6. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. multiple organ transplantation 2. Patients with previous allergies to sirolimus and its derivatives 3. (TG)>300 mg/dL;(TC)>350 mg/dL 4. Severe local or systemic infection 5. Known HIV infection 6. Platelet 0.8g/day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| acute rejection;BK polyomavirus infection rate;Incidence of BK polyomavirusassociated nephropathy;blood pressure control;fasting blood-glucose;lipid management;management of albuminuria; | — |
Countries
China
Contacts
Public ContactYang Hongji
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital People’s Hospital
Outcome results
None listed