Cesarean section
Conditions
Interventions
Esketamine group:Saline 20 ml micro pumping 10 minutes followed by intravenous push of 0.25 mg/kg esketamine.
Dexmedetomidine combined with esketamine group:Dexmedetomidine 0.5ug/kg diluted to 20ml micropumped 10 minutes followed by intravenous push of 0.25mg/kg esketamine.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women over 18 years old 2. Full-term singleton pregnancy 3. Planned cesarean section under spinal anesthesia 4. Agree to participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. BMI>27 kg/m^2 2. Previous mental disease, central nervous system disease, liver and kidney dysfunction, cardiopulmonary dysfunction, diabetes, or ASA>Grade III 3. Serious obstetric complications such as preeclampsia and eclampsia, gestational hypertension, placenta previa or placental abruption 4. Stillbirth or neonatal malformation 5. Contraindications for spinal anesthesia, including coagulation dysfunction, anticoagulant therapy, severe hypovolemia or hemodynamic instability 6. Unable to cooperate with researchers for any reason, such as hearing or visual impairments, language comprehension difficulties, etc 7. Known history of allergies and contraindications to the investigational drug 8. Heart rate below 50 beats per minute, presence of abnormal cardiac conduction or rhythm, such as sick sinus syndrome and preoperative hypotension (defined as systolic blood pressure<90 mm Hg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychiatric symptoms associated with esketamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative adverse events;Intraoperative maternal satisfaction score;Additional postoperative analgesics;Postoperative pain score;EPDS Rating;Insomnia Severity Index (ISI);Time to first postoperative anal defecation;Postoperative lactation time;Length of postoperative hospitalization; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
Department of Anesthesiology, The First Afliated Hospital of Anhui Medical University
Outcome results
None listed