Postoperative delirium
Conditions
Interventions
Ephedrine:Intraoperative correction of hypotension with ephedrine
Phenylephrine:Intraoperative correction of hypotension with phenylephedrine
Sponsors
Zigong Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Patients undergoing elective orthopedic lower limb joint replacement surgery, with a surgery time of = 2 hours; ? Age between 65 and 80 years old, BMI between 18-30 kg/m², gender not limited; ? ASA = Level 3; ? Expected postoperative hospitalization time = 3 days.
Exclusion criteria
Exclusion criteria: ? Patients with a history of alcohol, sedatives, analgesics, psychotropic drugs, or drug abuse and addiction; ? Patients with language, hearing, neurological or cognitive impairments who are unable to communicate correctly; ? Patients with language, hearing, neurological or cognitive impairments who are unable to communicate correctly; ? Combined important organ dysfunction, such as heart failure, severe liver or kidney failure (such as Child Pugh grade C or estimated glomerular filtration rate below 60 ml · min-1 per 1.73 m2); ? Individuals allergic to ephedrine or norepinephrine; ? Unable to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of vasoactive drugs used during surgery;Subtype of delirium;Delirium duration;Intraoperative changes in vital signs;The incidence of adverse events;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactSong Jianli
Zigong Fourth People's Hospital
Outcome results
None listed