Helicobector pylori
Conditions
Interventions
Levofloxacin-based dual therapy group.:Levofloxacin 50mg per dose, twice a day, orally taken half an hour before breakfast and dinner
Amoxicillin capsules 1000mg per dose, three times a day, orally taken half an hour after breakfast, lunch, and dinner. Oral administration for 14 days.
Bismuth-based quadruple therapy group.:Lansoprazole 30mg per dose, twice a day, orally taken half an hour before breakfast and dinner
Bismuth potassium citrate capsules 240mg per dose, twice a day, orally taken half an hour before breakfast and dinner
Clarithromycin tablets 500mg per dose, twice a day, orally taken half an hour after breakfast and dinner
Amoxicillin capsules 1000mg per dose, twice a day, orally taken half an hour after breakfast and dinner.
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 69 years old; 2. Individuals with a positive result in the 13C or 14C breath test, or confirmed as Helicobacter pylori infection through at least two of the following methods: rapid urease test, histopathology, Hp culture, and fecal Hp antigen test; 3. Have not received eradication therapy for Helicobacter pylori in the past; 4. Willing to undergo anti-Hp treatment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals allergic to any investigational drug; 2. Individuals who have undergone partial or total gastrectomy; 3. Individuals with significant organ dysfunction such as respiratory, cardiac, hepatic, renal insufficiency, etc.; 4. Individuals who have used antibiotics or corticosteroids within 4 weeks prior to enrollment, or acid suppressants within 2 weeks prior to enrollment; 5. Pregnant or lactating women; 6. Individuals who are unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13C-UBT; | — |
Secondary
| Measure | Time frame |
|---|---|
| compliance; | — |
Countries
China
Contacts
Public ContactJi Li
The First Affiliated Hospital of Xiamen University
Outcome results
None listed