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Alveolar nitric oxide combined with eosinophilic granulocyte assay guides glucocorticoid use in patients with acute exacerbation of chronic obstructive pulmonary disease

Alveolar nitric oxide combined with eosinophilic granulocyte assay guides glucocorticoid use in patients with acute exacerbation of chronic obstructive pulmonary disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400088787
Enrollment
Unknown
Registered
2024-08-27
Start date
2023-07-02
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease (COPD)

Interventions

AECOPD experimental group(Group ABCD):Intravenous glucocorticoids
COPD Stabilization Group:None
Health Group:None

Sponsors

The Second People's Hospital of Fuyang City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Healthy people; patients over 40 years of age with stable COPD diagnosed by pulmonary function; patients with a clear diagnosis and no history of acute exacerbation in the last 3 months, and patients with regular inhalation medication for AECOPD. All those who voluntarily participate and can complete the trial.

Exclusion criteria

Exclusion criteria: Patients with chronic cough (more than 8 weeks of illness), bronchial asthma, bronchiectasis, lung cancer, sleep apnea-hypopnea syndrome caused by various causes; Patients with long-term oral or intravenous glucocorticoids, allergy to glucocorticoids, coronary heart disease, hypertension, heart failure and diabetes, liver and kidney diseases.

Design outcomes

Primary

MeasureTime frame
alveolar nitric oxide;eosinophil count;

Countries

China

Contacts

Public ContactYa Shen

The Second People's Hospital of Fuyang City

fyeysy@163.com+86 130 9334 0370

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026