Reapplying tourniquets during surgery
Conditions
Interventions
Remote ischemic preconditioning group (Group RIPC):The group RIPC was treated with RIPC 1h before the operation completely blocked the blood supply of the operative limb. Place the tourniquet 2.5cm a
Control group (Group CON):In the group CON, the tourniquet was attached 1 hour before the operation to completely block the blood supply of the operative limb, but no operation was performed.
Sponsors
Department of Anesthesiology, No. 988 Hospital of Logistic Support Force of PLA
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: ?For patients undergoing general anesthesia for extremity surgery, tourniquets were applied twice and each time was > 40min. ?Age 20-50 years old. ?BMI 20-30kg/m2. ?ASA grades I-II.
Exclusion criteria
Exclusion criteria: ? Patients with underlying diseases such as diabetes and hypertension. ? Patients with preoperative vascular lesions involving upper limbs. ? Patients with mental system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin-like growth factor-binding protein-7 (IGFBP-7);Neutrophil gelatinase-associated lipocalin (NGAL); | — |
Secondary
| Measure | Time frame |
|---|---|
| Tissue inhibitor of metalloproteinases-2 (TIMP-2);Kidney Injury Molecule-1 (KIM-1); Interleukin-18 (IL-18);Serum cystatin-C (Cys-C) ;Blood Urea Nitrogen (BUN);Serum creatinine (SCr) ;Malondialdehyde(MDA);Superoxide dismutase (SOD); | — |
Countries
China
Contacts
Public ContactZhang Yang
Department of Anesthesiology, No. 988 Hospital of Logistic Support Force of PLA
Outcome results
None listed