drug induced pruritus
Conditions
Interventions
Part I. Pruritus Group:Intrathecal opioids
Part I. Not Pruritus Group:Intrathecal opioids
Part II. Group:Intrathecal opioids
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Voluntary participation, the patient understands and signs the informed consent form or signed by his immediate family members; 2.Age: 18-80 years old; 3.Tumor etiology; 4.Voluntary endospinal tube analgesia for continuous intrathecal morphine therapy, with no contraindications related to surgery.
Exclusion criteria
Exclusion criteria: 1.History of pruritus: previous skin diseases, chronic urticaria, chemotherapy-related pruritus and erythema, cholestatic pruritus, diabetic pruritus, etc.; 2.Contraindications to endospinal tube analgesia: hypocoagulability (PT prolongation >3s, APTT prolongation >10s, TT prolongation >3s, or platelet <75×10^9/L); Severe hemodynamic instability, history of spinal cord-related diseases such as sepsis, intracranial hypertension, spinal tuberculosis, cerebrospinal fluid outflow, and unsuitable puncture and catheterization such as tumor proximity to the puncture site; 3.Bilirubin and other related biochemical indicators increased; 4.Combined with severe mental illness, severe neurosis, pregnancy, and rheumatic and immunological diseases; 5.Recent allergic events; Patients who have received allogeneic blood transfusion in the past month; 6.Patients who lack consciousness, lack of understanding or expression ability, and cannot complete follow-up; Patients with abnormal limb autonomic mobility disorders or sensory deficits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequencing of the opioid receptor MOR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Itching, pain scale scores; | — |
Countries
China
Contacts
Public ContactCang Jing
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed