Sepsis cardiomyopathy
Conditions
Interventions
experimental group:shenfu injection was given 200ml/d for 7 days
control group:conventional treatment according to guidelines for sepsis and septic shock
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Age: ?60 years old; (2) Sepsis was diagnosed (according to sepsis 3.0 diagnostic criteria: infection caused host response disorder, resulting in life-threatening organ function damage); (3) There is no sepsis cardiomyopathy (diagnostic criteria for sepsis cardiomyopathy: there is no unified diagnostic criteria at present, which is defined as excluding acute coronary syndrome and stress cardiomyopathy based on previous studies. Cardiac ultrasound showed left ventricular systolic dysfunction, and EF<50% or cTnI higher than 2 times the normal value); (4) Informed consent signed by the patient or his/her agent.
Exclusion criteria
Exclusion criteria: (1) Patients with allergic history or contraindications to Shenfu injection (such as recent history of cerebral hemorrhage); (2) pregnant women; (3) Patients unable to complete bedside cardiac ultrasound examination for various reasons; (4) Patients after cardiac surgery; (5) The patient concurrently participates in another clinical study; (6) Patients with serious underlying heart disease, such as dilated heart disease, valvular disease, ventricular septal defect, congenital heart disease, etc. (7) Patients who can expect to die within 48 hours; (8) Patients considered unsuitable for the study by the researcher for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sepsis cardiomyopathy; | — |
Secondary
| Measure | Time frame |
|---|---|
| When sepsis cardiomyopathy occurs;7 days heart function recovery rate;14 days heart function recovery rate;28-day mortality rate; | — |
Countries
China
Contacts
Public ContactJing Wang
Zhongnan Hospital of Wuhan University
Outcome results
None listed