perioperative hypotension
Conditions
Interventions
Systolic blood pressure group:Maintain systolic blood pressure at the baseline level of ±20%, if the target value is < 100mmHg, 100mmHg is used as the lower limit of the target value.
Mean arterial pressure group:Maintain mean arterial pressure at baseline ±20%, with 65mmHg as the lower limit if the target value is < 65mmHg.
Sponsors
Zhongda Hospital affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.The age ranged from 65 to 85 years,no gender limit 2.Major abdominal surgery is planned under general anesthesia, with an expected operation time of more than 2 hours and an expected hospital stay of at least 3 days 3.American Standards Association (ASA) classification: ASA class I to ? 4. After comprehensively understanding of the objectives and importance of this research,patients voluntarily participated in this clinical trial and informed consent was obtained
Exclusion criteria
Exclusion criteria: 1.Chronic kidney disease (glomerular filtration rate <30ml/min/1.73m^2 or end-stage renal disease requiring renal replacement therapy) 2.Severe chronic obstructive pulmonary disease, acute respiratory distress syndrome with hypoxemia 3.Acute or decompensated heart failure, acute coronary syndrome, severe arrhythmia, valvular disease with severe hemodynamic disturbances 4.The preoperative diagnosis was dementia, cognitive impairment, or a history of psychiatric illness 5.The preoperative diagnosis was sepsis or shock state with continuous infusion of vasoactive agents 6.Surgery required for controlled hypotension(e.g., hepatectomy) 7.Minor abdominal surgery (e.g., laparoscopic cholecystectomy) 8.General anesthesia was combined with spinal anesthesia 9.Additional medical conditions were determined to be ineligible for inclusion by researchers 10.Participated in other clinical studies in the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of new organ dysfunction after surgery ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and duration of intraoperative hypotension (defined as less than 20% of the target value);The number and duration of intraoperative hypertension (defined as 20% above the target value);SOFA, Glasgow, 3D-CAM score and Kdigo stage at 1, 2 and 7 days after surgery((If the duration of hospitalization after surgery was less than 7 days, the assessment was made on the 1st and 2nd day after surgery and the 1st day before discharge);Incidence of vital organ dysfunction within 30 days after surgery;The incidence of surgery-related complications within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactJie Sun
Zhongda Hospital affiliated to Southeast University
Outcome results
None listed