primary Sjogren syndrome
Conditions
Interventions
Gold Standard:Western medical diagnostic criteria: in line with the 2016 ACR/EULAR classification of primary Sjogren's syndrome.
Diagnostic criteria of blood stasis in traditional Chinese medicine: ac
Sponsors
Yueyang Hospital of Integrated Chinese and Western medicine, Shanghai University of Traditional Chinese medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All included pSS patients met the pSS classification criteria of ACR/EULAR in 2016; 2. Meet the diagnostic standards of Western medicine and improve relevant examinations; 3. Meet the diagnostic criteria of dryness in TCM; 4. Age =18 years old; 5. Age =75 years.
Exclusion criteria
Exclusion criteria: 1 sSS or patients with other rheumatological diseases, diabetes or local salivary gland diseases; 2 Patients with acute parotitis, salivary gland tumor and other salivary gland lesions; 3. The following diseases that may interfere with clinical diagnosis should be excluded: 1)History of head and neck radiotherapy; 2)Active hepatitis C virus infection (confirmed by PCR); 3)AIDS; 4) sarcoidosis; 5)Amyloidosis;6) Graft-versus-host disease; 7) IGG4-associated diseases. Other cases that affect the salivary gland display and cannot be scored by ultrasound; 4. People with serious lesions or disabilities of vital organs caused by other reasons; 5 Patients with diabetes and malignant tumors; 6 Patients lacking SGUS and LSGB results; 7 Patients with interval of more than 3 months between SGUS and LSGB; 8 Patients who had been treated with hormones or immunosuppressants before;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| unstimulated salivary flow rate;antiSSA(Ro) antibodies,;minor labial salivary gland biopsy;focus score;OMERACT major salivary gland ultrasonography score;Hypoechoic mass size;blood stasis score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation rate;Complement;Immune globulin;Rheumatoid factor; | — |
Countries
China
Contacts
Public ContactXue Luan
Yueyang Hospital of Integrated Chinese and Western medicine, Shanghai University of Traditional Chinese medicine
Outcome results
None listed