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Comparison of clinical features between eyes with subretinal fibrosis and neovascular age-related macular degeneration: a case-control study

Risk factors for development of nAMD into subretinal fibrosis: a case-control study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400088749
Enrollment
Unknown
Registered
2024-08-26
Start date
2024-03-13
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AMD

Interventions

SRF secondaryto nAMD group, nAMD group:None

Sponsors

Xiyuan Hospital of China Academy of Chinese Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 95 Years

Inclusion criteria

Inclusion criteria: 1. Age range of 50-95 years old; 2. Meet the diagnostic criteria for nAMD: (a) discoidal exudation in the macula with repeated hemorrhages, visible neovascularization, decreased visual acuity, and loss of macular central recess reflex. (b) Fundus fluorescence angiography shows fluorescent leakage from neovascularization and masked fluorescence in the hemorrhagic area. 3. meet the diagnostic criteria for SRF secondary to nAMD: (a) A hyperreflective area located in the subretinal or sub-RPE interstitial space was visible on the OCT test. (b) Milky white or yellow material in the macular area is visible on CFP test. 4. Those who are capable of signing informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of the following: diabetic retinopathy, retinal vein occlusion, iridocyclitis, macular schisis, retinal detachment, and macular prefovea; 2. History of glaucoma or ocular trauma; 3. History of vitreous surgery or PDT treatment.

Design outcomes

Primary

MeasureTime frame
OCT test;color fundus photograph;

Secondary

MeasureTime frame
medical history;BCVA;

Countries

China

Contacts

Public ContactWu Sun

Xiyuan Hospital of China Academy of Chinese Medical Sciences

18717123259@163.com+86 178 0122 3057

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026