dental caries
Conditions
Interventions
Experimental group 1:Take live bacteria Lactobacillus plantarum (Lactobacillus plantarum KLDS1001, Lactobacillus plantarum JLA-9, Lactobacillus reuteri FPHC2951, Lactobacillus Swiss LZ-R-5) lozenges.
Experimental group 2:Take inactivated Lactobacillus plantarum (Lactobacillus plantarum KLDS1001, Lactobacillus plantarum JLA-9, Lactobacillus reuteri FPHC2951, Lactobacillus Swiss LZ-R-5) lozenges (co
Control group:Edible blank auxiliary material
Sponsors
Xiangya School of Stomatology, Central South University, Hunan
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Gender is not limited, age between 18 and 70 years old; 2. Good oral hygiene, no abnormal dental structure 3. Healthy people who have not been clinically diagnosed as "caries" (can suffer from other oral diseases) according to their medical history and clinical examination; 4. Good compliance, willing to keep follow-up; 5. Be willing to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Volunteers participate in other medical research projects at the same time; 2 Allergic to plant probiotics; 3. People with mental illness or cognitive impairment; 4 Patients who could not follow the doctor's advice to use probiotic oral lozenges and return to the doctor on time; 5 Pregnant and lactating women; 6. Those who have used immunomodulators and hormone drugs within three months; 7 Patients who have not recovered from major surgery recently; 8 Known history of primary immunodeficiency; 9 known to have active tuberculosis; 10 Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation; 11 Known HIV infected persons and carriers (HIV antibody positive); 12 Known hepatitis B infection and carriers (Dasanyang and Xiaosanyang) 13 Serious infections that are active or poorly controlled clinically; Symptomatic congestive heart failure (New York Heart Association Grade II) or symptomatic or poorly controlled arrhythmias; 15 The researchers considered that other reasons were not suitable for this researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flora abundance;Salivary pH;Plaque index;Caries risk assessment;Oral health self-assessment questionnaire; | — |
Countries
China
Contacts
Public ContactWang Yuehong
Xiangya School of Stomatology, Central South University, Hunan
Outcome results
None listed