Large B-cell lymphoma
Conditions
Interventions
Prospective samples collection group:NA
Retrospective data collection group:NA
Sponsors
Beijing GoBroad Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed large B-cell lymphoma, including diffuse large B-cell lymphoma, or diffuse large B-cell lymphoma with secondary central nervous system involvement, or transformed follicular lymphoma, or primary mediastinal large B-cell lymphoma, or primary mediastinal large B-cell lymphoma with CNS involvement, or high-grade B-cell lymphoma with MYC and BCL2 or BCL6 translocation; 2. Relapsed or refractory patients, defined as those who failed to achieve complete response (CR) or relapsed early after standard immunochemotherapy (such as R-CHOP or similar therapies); 3. Evaluable lesions (Lugano 2014 as evaluation criteria); 4. For the portion that residual tumor tissue samples and residual CD19 CAR T cell products need to be collected, patients are required to sign the Informed Consent Form(ICF) and are available to provide at least one of the two options: the remaining tumor tissue or the residual CAR T cell products.
Exclusion criteria
Exclusion criteria: 1. Other diagnosis of non-Hodgkin lymphoma besides inclusion criteria; 2. Patients who have used other CART cell therapy or other gene-modified cell therapy before first receiving CD19 CART cell.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAR-T product exhaustion status;dynamic change in CAR T copy number;dynamic change in CAR T cells in peripheral blood;dynamic change in subclusters of CAR T cells and their checkpoints expression in peripheral blood;tumor CD19 expression;dynamic change of tumor microenvironment post-CAR T infusion;tumor infiltrating endogenous T cell subcluster and exhaustion status;CAR-T product exhaustion status; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAR-T product subclusters; | — |
Countries
China
Contacts
Public ContactKai Hu
Beijing GoBroad Hospital
Outcome results
None listed